OTC Analgesics May Reduce Depression Symptoms


Used alongside antidepressants, OTC analgesics and anti-inflammatories purchased from pharmacies may effectively treat patients with depression without increasing their risk of adverse events, the results of a large meta-analysis suggest.

Across the 14 international trials on the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and cytokine inhibitors that were included in the meta-analysis, OTC anti-inflammatory treatment reduced depressive symptoms compared with placebo in patients who were diagnosed with depression or exhibiting depressive symptoms.

Among the 6 studies that reported on adverse events, the researchers found no evidence of increased amounts of gastrointestinal or cardiovascular events or infections with OTC anti-inflammatory treatment versus placebo.

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