One Dose of Antidepressant Changes the Brain, Study Finds | TIME

All these years I’ve told doctors that I can feel the effects of anti-depressants overnight, they refused to believe me, but here is proof that changes happen right away.

All the years I’ve struggled with my pain, fatigue, and mood, no one would believe what I told them – yet it’s all being proven true now as science develops better tools. If they had listened to me 20 years ago, I could have saved them decades of ignorance :-)

By the way, giving these meds to non-depressed people is of course different than giving them to the severely depressed. And of course these changes they see are fleeting as the body works to return to homeostasis. If we were able to scan the brain continuously, I’m sure we’d find it doesn’t work the way we believe it does.

I was right!


One dose of antidepressant is all it takes to change the brain, finds a small new study published in the journal Current Biology.

The study authors took brain scans of 22 healthy people who weren’t depressed and who had never before taken antidepressants. Some were randomized to take a dose of the most common kind of antidepressant, an SSRI (selective serotonin reuptake inhibitors).

After another brain scan three hours later, researchers saw a dramatic change: a widespread drop in connectivity throughout the brain, except where it was enhanced in two brain regions, the cerebellum and thalamus.

The results suggest that antidepressants may alter brain connections much faster than previously thought. “We were surprised,” says study author Julia Sacher, of the Max Planck Institute for Human Cognitive and Brain Sciences, in an email to TIME. “We were not expecting the SSRI to have such a prominent effect on such a short time-scale and the resulting signal to encompass the entire brain.”

Antidepressants are generally thought to take several weeks to kick in. “It is possible that these connectivity changes are the first step in remodeling the brain, as there is evidence from other experiments that such functional connectivity changes can reflect neuroplastic change,” Sacher says.

“However, much work remains before we understand how different antidepressants affect the brains of people with and without depression, not only after the first dose, but also over the longer term. The hope that we have for future studies is to uncover distinct differences in brain connectivity between depression patients who ultimately respond to an antidepressant and those who do not.”

Sent from my iPad


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